Interaction between thyroglobulin andADAMTS16in premature ovarian failure

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Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure

OBJECTIVE The aim of the present study was to examine whether interactions between polymorphisms in the thyroglobulin and ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) genes are associated with the development of premature ovarian failure (POF). METHODS A total of 75 patients with POF and 196 controls were involved in this study. We used a GoldenGate assay to genotype ...

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Ovarian transplantation between monozygotic twins discordant for premature ovarian failure.

Monozygotic 24-year-old twins presented with discordant ovarian function. One had had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after tran...

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Autoimmune premature ovarian failure

Premature ovarian failure (POF), also termed as primary ovarian insufficiency (POI), is a highly heterogenous condition affecting 0.5-3.0% of women in childbearing age. These young women comprise quite a formidable group with unique physical and psychological needs that require special attention. Premature ovarian senescence (POS) in all of its forms evolves insidiously as a basically asymptoma...

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Premature ovarian failure

Premature ovarian failure is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles/arrested folliculogenesis before the age of 40 years (secondary amenorrhea). Hormonally, POF is defined by abnormally low levels of estrogen and high levels of FSH, which demonstrate that the ovaries are no longer responding to circul...

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Premature ovarian failure.

On average, the menopause occurs at the age of 50 years, with 1% of women continuing to menstruate beyond the age of 60 years and 1% whose menopause occurs before 40 years. Arbitrarily, a menopause before the age of 40 years is defined as 'premature'.

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ژورنال

عنوان ژورنال: Clinical and Experimental Reproductive Medicine

سال: 2014

ISSN: 2233-8233,2233-8241

DOI: 10.5653/cerm.2014.41.3.120